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Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis

IntroductionOsteoclasts determine bone tissue turnover. Their increased activity causes osteoporosis, their dysfunction osteopetrosis.Methods and ResultsMurine monocytic ER-Hoxb8 cells differentiate into OCs upon treatment with M-CSF and RANKL and upregulate the collagen-binding integrin α2β1 distin...

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Principais autores: Katrin Brockhaus, Isabel Hemsen, Saskia-Larissa Jauch-Speer, Stephan Niland, Thomas Vogl, Johannes A. Eble
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2024-08-01
Serija:Frontiers in Cell and Developmental Biology
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Online dostop:https://www.frontiersin.org/articles/10.3389/fcell.2024.1448725/full
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