Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Abstract Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based information on disease specific cellular phenotypes is...

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Detalhes bibliográficos

Principais autores:	Markus Schulze, Annika Sommer, Sonja Plötz, Michaela Farrell, Beate Winner, Janina Grosch, Jürgen Winkler, Markus J. Riemenschneider
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-07-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Methylation PD Induced pluripotent stem cells iPSC SINE LINE
Acesso em linha:	http://link.springer.com/article/10.1186/s40478-018-0561-x
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