The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the aging brain and is a feature of HD. We soug...

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Principais autores:	Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-09-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	Huntington (disease) iPSC (induced pluripotent stem cell) primary neuron culture mouse models of disease neurodegenaration DNA damage
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnagi.2020.524369/full
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