Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification

Abstract Huntington disease (HD) is a progressive and devastating neurodegenerative disease caused by expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene above a critical threshold of ~ 35 repeats resulting in expression of mutant HTT (mHTT). A promising treatment approach being t...

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Principais autores:	Rachel J. Harding, Yuanyun Xie, Nicholas S. Caron, Hailey Findlay-Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R. Hayden, Blair R. Leavitt, Douglas R. Langbehn, Amber L. Southwell
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-04-01
Series:	Biomarker Research
Assuntos:	Huntington’s Disease Biomarkers Huntingtin Detection Huntingtin Lowering Therapies
Acceso en liña:	https://doi.org/10.1186/s40364-025-00772-4
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