The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the aging brain and is a feature of HD. We soug...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2020-09-01
سلاسل:	Frontiers in Aging Neuroscience
الموضوعات:	Huntington (disease) iPSC (induced pluripotent stem cell) primary neuron culture mouse models of disease neurodegenaration DNA damage
الوصول للمادة أونلاين:	https://www.frontiersin.org/article/10.3389/fnagi.2020.524369/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!