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Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease

In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is, accordingly, growing recognition that HD is a systemic disorder with functional inte...

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Principais autores: Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R. Hayden, Amber L. Southwell
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-01-01
Serier:Neurobiology of Disease
Fag:
Huntington disease
Immunotherapy
Passive immunization
Huntingtin lowering therapy
Extracellular huntingtin
Transgenic mice
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996123003923
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