Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease

In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is, accordingly, growing recognition that HD is a systemic disorder with functional inte...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R. Hayden, Amber L. Southwell
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2024-01-01
سلاسل:	Neurobiology of Disease
الموضوعات:	Huntington disease Immunotherapy Passive immunization Huntingtin lowering therapy Extracellular huntingtin Transgenic mice
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S0969996123003923
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!