Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance

Abstract Our study elucidates the role of FOXP1 in chemoresistance in small cell lung cancer(SCLC). FOXP1 enhances chemoresistance by regulating SP8 expression through its super-enhancer (SP8-SE), with SP8 mediating resistance via the homologous recombination repair (HRR) pathway. We also discovered...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Yichun Tang, Yuchun Niu, Yi Chen, Xuyang Zhou, Yueyang Hu, Lei Sun, Yan Xiong, Yue Xu, Qiongyao Wang, Yu Wang, Linlang Guo
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-03-01
Цуврал:	Communications Biology
Онлайн хандалт:	https://doi.org/10.1038/s42003-025-07804-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!