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Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway

Objective: This study aimed at exploring the effects of the epigenetic regulator, chidamide, on reprogramming the immunosuppressive tumor microenvironment in small cell lung cancer (SCLC), particularly the roles in macrophage polarization and angiogenesis. The therapeutic efficacy of combining chida...

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Principais autores: Wenting Liu, Ting Mei, Yantao Jiang, Jingya Wang, Mengjie Li, Liuchun Wang, Zhaoting Meng, Tingting Qin, Dingzhi Huang
Format: Artigo
Sprog:Inglês
Udgivet: China Anti-Cancer Association 2025-12-01
Serier:Cancer Biology & Medicine
Fag:
sclc
chidamide
ccl2
macrophage
tumor immune microenvironment
stat4
Online adgang:https://www.cancerbiomed.org/content/22/12/1578
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