Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway

Objective: This study aimed at exploring the effects of the epigenetic regulator, chidamide, on reprogramming the immunosuppressive tumor microenvironment in small cell lung cancer (SCLC), particularly the roles in macrophage polarization and angiogenesis. The therapeutic efficacy of combining chida...

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Autori principali:	Wenting Liu, Ting Mei, Yantao Jiang, Jingya Wang, Mengjie Li, Liuchun Wang, Zhaoting Meng, Tingting Qin, Dingzhi Huang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	China Anti-Cancer Association 2025-12-01
Serie:	Cancer Biology & Medicine
Soggetti:	sclc chidamide ccl2 macrophage tumor immune microenvironment stat4
Accesso online:	https://www.cancerbiomed.org/content/22/12/1578
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