Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance

Abstract Our study elucidates the role of FOXP1 in chemoresistance in small cell lung cancer(SCLC). FOXP1 enhances chemoresistance by regulating SP8 expression through its super-enhancer (SP8-SE), with SP8 mediating resistance via the homologous recombination repair (HRR) pathway. We also discovered...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Yichun Tang, Yuchun Niu, Yi Chen, Xuyang Zhou, Yueyang Hu, Lei Sun, Yan Xiong, Yue Xu, Qiongyao Wang, Yu Wang, Linlang Guo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-03-01
Edice:	Communications Biology
On-line přístup:	https://doi.org/10.1038/s42003-025-07804-7
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!