Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance
Abstract Our study elucidates the role of FOXP1 in chemoresistance in small cell lung cancer(SCLC). FOXP1 enhances chemoresistance by regulating SP8 expression through its super-enhancer (SP8-SE), with SP8 mediating resistance via the homologous recombination repair (HRR) pathway. We also discovered...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2025-03-01
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| coleção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-025-07804-7 |
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