Metabolic engineering of Streptomyces albulus for de novo serotonin production

Abstract Background Serotonin (5-hydroxytryptamine, 5-HT) is a pivotal neurotransmitter with broad clinical relevance. However, its industrial-scale microbial production remains a significant challenge. In this study, we engineered Streptomyces albulus to develop an efficient enzymatic cascade for t...

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Bibliographic Details

Main Authors:	Yuan Zhang, Aoxiang Liu, Min Zhang, Jiabei Song, Qian Wang, Yongxuan Liu, Qingshou Yao, Linghui Kong, Xiuwen Wang, Jiayang Qin
Format:	Artigo
Language:	Inglês
Published:	BMC 2026-03-01
Series:	Microbial Cell Factories
Subjects:	Serotonin Streptomyces albulus Metabolic engineering Multi-enzyme cascade Biosynthesis Fed-batch
Online Access:	https://doi.org/10.1186/s12934-026-02995-y
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