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Metabolic engineering of Streptomyces albulus for de novo serotonin production

Abstract Background Serotonin (5-hydroxytryptamine, 5-HT) is a pivotal neurotransmitter with broad clinical relevance. However, its industrial-scale microbial production remains a significant challenge. In this study, we engineered Streptomyces albulus to develop an efficient enzymatic cascade for t...

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Hoofdauteurs: Yuan Zhang, Aoxiang Liu, Min Zhang, Jiabei Song, Qian Wang, Yongxuan Liu, Qingshou Yao, Linghui Kong, Xiuwen Wang, Jiayang Qin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2026-03-01
Reeks:Microbial Cell Factories
Onderwerpen:
Serotonin
Streptomyces albulus
Metabolic engineering
Multi-enzyme cascade
Biosynthesis
Fed-batch
Online toegang:https://doi.org/10.1186/s12934-026-02995-y
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