Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2021-09-01
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| 叢編: | Acta Pharmaceutica Sinica B |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2211383520307656 |
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