Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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Главные авторы:	Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2021-09-01
Серии:	Acta Pharmaceutica Sinica B
Предметы:	Protein arginine methyltransferase 5 Protein arginine methyltransferase 4 Bisubstrate analogue Protein arginine methyltransferase Bisubstrate inhibitor
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211383520307656
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