Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

Szczegółowa specyfikacja

Opis bibliograficzny

Główni autorzy:	Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2021-09-01
Seria:	Acta Pharmaceutica Sinica B
Hasła przedmiotowe:	Protein arginine methyltransferase 5 Protein arginine methyltransferase 4 Bisubstrate analogue Protein arginine methyltransferase Bisubstrate inhibitor
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2211383520307656
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!