Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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Detalhes bibliográficos

Principais autores:	Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-09-01
Colecção:	Acta Pharmaceutica Sinica B
Assuntos:	Protein arginine methyltransferase 5 Protein arginine methyltransferase 4 Bisubstrate analogue Protein arginine methyltransferase Bisubstrate inhibitor
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383520307656
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