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Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Abstract Background Elevated lactate is associated with vascular endothelial dysfunction, a factor that can contribute to organ failure in sepsis. However, the specific mechanisms involved have yet to be fully elucidated. Here, we investigated the role of enolase 1 (ENO1) lactylation in modulating t...

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Principais autores: Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2026-01-01
Series:Clinical and Translational Medicine
Assuntos:
endothelial dysfunction
ENO1
lactylation
sepsis
Acceso en liña:https://doi.org/10.1002/ctm2.70597
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