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Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma

Background & Aims: The inhibition of epigenetic regulators activates endogenous retrovirus (ERV) expression, which can stimulate a viral mimicry response in cancer cells. ERV elements are aberrantly expressed in hepatocellular carcinoma (HCC); however, the expression of ERVs regulated by histone...

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Asıl Yazarlar: Yosuke Igarashi, Yoshimitsu Akiyama, Shu Shimada, Shuichi Watanabe, Megumi Hatano, Keita Kodera, Kohei Okazaki, Yoshiaki Tanji, Shu Tsukihara, Tomohiko Taniai, Atsushi Nara, Masahiro Yamane, Atsushi Kamachi, Kentaro Umemura, Koya Yasukawa, Hiroaki Ono, Keiichi Akahoshi, Minoru Tanabe, Koichiro Haruki, Kenei Furukawa, Toru Ikegami, Shinji Tanaka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-03-01
Seri Bilgileri:JHEP Reports
Konular:
Viral mimicry
Interferon
Tumor immunity
Histone modification
Endogenous retrovirus
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2589555924003112
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