Compound KTI-2338 Inhibits ACVR1 Receptor Signaling in Fibrodysplasia Ossificans Progressiva

<b>Background/Objectives:</b> Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic bone disorder, leading to progressive immobilization through the formation of bone in muscles, tendons, and ligaments. A variant in the <i>ACVR1</i> gene results in a constitutively overactive ALK2 receptor,...

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Autors principals:	Neeltje M. Rosenberg, Lidiia Zhytnik, Lisanne E. Wisse, Esmée Botman, Jennifer L. Lachey, E. Marelise W. Eekhoff, Dimitra Micha
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-12-01
Col·lecció:	Pharmaceutics
Matèries:	fibrodysplasia ossificans progressiva fibroblasts activin A BMP heterotopic ossification ACVR1
Accés en línia:	https://www.mdpi.com/1999-4923/17/12/1590
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