Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity

IntroductionThe development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In this study, newly synthesized derivatives incorporating bis-indole and pyrazolo[3,4-b]pyridine scaffolds were evaluated for their antiproliferative potent...

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Principais autores:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Miroslav Peřina, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Veronika Vojáčková, Mostafa M. Elbadawi, Moataz A. Shaldam, Vladimír Kryštof, Hatem A. Abdel-Aziz
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Pharmacology
Assuntos:	bis-indole leukemia molecular modeling synergistic therapy topoisomerase inhibitors
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1745220/full
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