Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity

IntroductionThe development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In this study, newly synthesized derivatives incorporating bis-indole and pyrazolo[3,4-b]pyridine scaffolds were evaluated for their antiproliferative potent...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Miroslav Peřina, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Veronika Vojáčková, Mostafa M. Elbadawi, Moataz A. Shaldam, Vladimír Kryštof, Hatem A. Abdel-Aziz
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2026-03-01
Σειρά:	Frontiers in Pharmacology
Θέματα:	bis-indole leukemia molecular modeling synergistic therapy topoisomerase inhibitors
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1745220/full
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