Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity

IntroductionThe development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In this study, newly synthesized derivatives incorporating bis-indole and pyrazolo[3,4-b]pyridine scaffolds were evaluated for their antiproliferative potent...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Miroslav Peřina, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Veronika Vojáčková, Mostafa M. Elbadawi, Moataz A. Shaldam, Vladimír Kryštof, Hatem A. Abdel-Aziz
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2026-03-01
سلاسل:	Frontiers in Pharmacology
الموضوعات:	bis-indole leukemia molecular modeling synergistic therapy topoisomerase inhibitors
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1745220/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!