Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity

IntroductionThe development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In this study, newly synthesized derivatives incorporating bis-indole and pyrazolo[3,4-b]pyridine scaffolds were evaluated for their antiproliferative potent...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Miroslav Peřina, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Veronika Vojáčková, Mostafa M. Elbadawi, Moataz A. Shaldam, Vladimír Kryštof, Hatem A. Abdel-Aziz
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-03-01
Edice:	Frontiers in Pharmacology
Témata:	bis-indole leukemia molecular modeling synergistic therapy topoisomerase inhibitors
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1745220/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!