Natural Sesquiterpene Lactones of the 4,15-<i>iso</i>-Atriplicolide Type are Inhibitors of Trypanothione Reductase

In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15-<i>iso</i>-Atriplicolide tiglate, which demonstrated an IC₅₀ value of 15 nM against <i>Trypanosoma brucei rhodesien...

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Principais autores:	Mairin Lenz, R. Luise Krauth-Siegel, Thomas J. Schmidt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-10-01
coleção:	Molecules
Assuntos:	sesquiterpene lactone 4,15-iso-atriplicolide ester <i>trypanosoma brucei</i> <i>trypanosoma cruzi</i> trypanothione reductase irreversible inhibitor antitrypanosomal activity
Acesso em linha:	https://www.mdpi.com/1420-3049/24/20/3737
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