Natural Sesquiterpene Lactones of the 4,15-<i>iso</i>-Atriplicolide Type are Inhibitors of Trypanothione Reductase

In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15-<i>iso</i>-Atriplicolide tiglate, which demonstrated an IC₅₀ value of 15 nM against <i>Trypanosoma brucei rhodesien...

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Bibliografiske detaljer

Principais autores:	Mairin Lenz, R. Luise Krauth-Siegel, Thomas J. Schmidt
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2019-10-01
Serier:	Molecules
Fag:	sesquiterpene lactone 4,15-iso-atriplicolide ester <i>trypanosoma brucei</i> <i>trypanosoma cruzi</i> trypanothione reductase irreversible inhibitor antitrypanosomal activity
Online adgang:	https://www.mdpi.com/1420-3049/24/20/3737
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