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Natural Sesquiterpene Lactones of the 4,15-<i>iso</i>-Atriplicolide Type are Inhibitors of Trypanothione Reductase

In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15-<i>iso</i>-Atriplicolide tiglate, which demonstrated an IC<sub>50</sub> value of 15 nM against <i>Trypanosoma brucei rhodesien...

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Hoofdauteurs: Mairin Lenz, R. Luise Krauth-Siegel, Thomas J. Schmidt
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2019-10-01
Reeks:Molecules
Onderwerpen:
sesquiterpene lactone
4,15-iso-atriplicolide ester
<i>trypanosoma brucei</i>
<i>trypanosoma cruzi</i>
trypanothione reductase
irreversible inhibitor
antitrypanosomal activity
Online toegang:https://www.mdpi.com/1420-3049/24/20/3737
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