Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is known that CFTR exit from the ER is mediated by sp...

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Autors principals:	João D. Santos, Sara Canato, Ana S. Carvalho, Hugo M. Botelho, Kerman Aloria, Margarida D. Amaral, Rune Matthiesen, Andre O. Falcao, Carlos M. Farinha
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2019-04-01
Col·lecció:	Cells
Matèries:	CFTR endoplasmic reticulum quality control arginine-framed tripeptides diacidic code interactome folding trafficking
Accés en línia:	https://www.mdpi.com/2073-4409/8/4/353
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