Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is known that CFTR exit from the ER is mediated by sp...

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Detalhes bibliográficos

Principais autores:	João D. Santos, Sara Canato, Ana S. Carvalho, Hugo M. Botelho, Kerman Aloria, Margarida D. Amaral, Rune Matthiesen, Andre O. Falcao, Carlos M. Farinha
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-04-01
coleção:	Cells
Assuntos:	CFTR endoplasmic reticulum quality control arginine-framed tripeptides diacidic code interactome folding trafficking
Acesso em linha:	https://www.mdpi.com/2073-4409/8/4/353
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