Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs

Abstract The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function, post malaria vaccination. We expressed 132 recombinant anti-Pfs230D1 h...

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Главные авторы:	Camila H. Coelho, Susanna Marquez, Bergeline C. Nguemwo Tentokam, Anne D. Berhe, Kazutoyo Miura, Vishal N. Rao, Carole A. Long, Ogobara K. Doumbo, Issaka Sagara, Sara Healy, Steven H. Kleinstein, Patrick E. Duffy
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2024-08-01
Серии:	npj Vaccines
Online-ссылка:	https://doi.org/10.1038/s41541-024-00929-6
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