Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs

Abstract The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function, post malaria vaccination. We expressed 132 recombinant anti-Pfs230D1 h...

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Bibliographic Details

Main Authors:	Camila H. Coelho, Susanna Marquez, Bergeline C. Nguemwo Tentokam, Anne D. Berhe, Kazutoyo Miura, Vishal N. Rao, Carole A. Long, Ogobara K. Doumbo, Issaka Sagara, Sara Healy, Steven H. Kleinstein, Patrick E. Duffy
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2024-08-01
Series:	npj Vaccines
Online Access:	https://doi.org/10.1038/s41541-024-00929-6
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