CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity

Natural Killer (NK) cells are innate immune cells that can directly detect and kill cancer cells. Understanding the molecular determinants regulating human NK cell cytotoxicity could help harness these cells for cancer therapies. To this end, we compared the transcriptome of NK cell clones derived f...

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Autors principals:	Camille Rey, Katherine L. Jones, Kevin B. Stacey, Alicia Evans, Jonathan D. Worboys, Gareth Howell, Sam Sheppard, Daniel M. Davis
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-02-01
Col·lecció:	Frontiers in Immunology
Matèries:	NK cells CD8 CD70 cytotoxicity RNA sequencing cancer immunotherapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526379/full
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