Identification and characterization of blocking nanobodies against human CD70

CD70 is overexpressed in a variety of solid and hematological tumors and plays a role in tumor proliferation and evasion of immune surveillance. Targeting and blocking its binding to the receptor CD27 have the potential to treat CD70-dependent tumors. To generate novel CD70 blocking agents, we scree...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Zhang Xin, Liu Chang, Xie Yuan, Hu Qianqian, Chen Yuanyuan, Li Jiangwei
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	China Science Publishing & Media Ltd. 2022-10-01
Цуврал:	Acta Biochimica et Biophysica Sinica
Нөхцлүүд:	CD70 CD27 nanobody phage display blocking antibody
Онлайн хандалт:	https://www.sciengine.com/doi/10.3724/abbs.2022141
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!