Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice

Down syndrome (DS) mouse models exhibit cognitive deficits, and are used for studying the neuronal basis of DS pathology. To understand the differences in the physiology of DS model neurons, we used dissociated neuronal cultures from the hippocampi of Ts65Dn and Tc1 DS mice. Imaging of [Ca2+]i and w...

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Autors principals:	Shani Stern, Menahem Segal, Elisha Moses
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-09-01
Col·lecció:	EBioMedicine
Matèries:	Down syndrome Ts65Dn Tc1 Potassium currents Potassium channels Inward rectifiers Reduced excitability Hippocampus
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2352396415300906
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