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Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory deficits and similar brain oxidative sta...

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Principais autores: Alba Puente-Bedia, María T. Berciano, Carmen Martínez-Cué, Miguel Lafarga, Noemí Rueda
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-12-01
coleção:Antioxidants
Assuntos:
Ts65Dn
hippocampus
down syndrome
granule cells
oxidative stress
DNA damage
Acesso em linha:https://www.mdpi.com/2076-3921/11/12/2438
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