Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone

Down syndrome (DS), a major genetic cause of intellectual disability, is characterized by numerous neurodevelopmental defects. Previous in vitro studies highlighted a relationship between bioenergetic dysfunction and reduced neurogenesis in progenitor cells from the Ts65Dn mouse model of DS, suggest...

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Ngā kaituhi matua:	Daniela Valenti, Fiorenza Stagni, Marco Emili, Sandra Guidi, Renata Bartesaghi, Rosa Anna Vacca
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2021-12-01
Rangatū:	Antioxidants
Ngā marau:	Down syndrome Ts65Dn mice brain mitochondria oxidative phosphorylation mitochondrial respiratory chain 7,8-dihydroxyflavone
Urunga tuihono:	https://www.mdpi.com/2076-3921/11/1/62
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!