Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory deficits and similar brain oxidative sta...

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Hlavní autoři:	Alba Puente-Bedia, María T. Berciano, Carmen Martínez-Cué, Miguel Lafarga, Noemí Rueda
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-12-01
Edice:	Antioxidants
Témata:	Ts65Dn hippocampus down syndrome granule cells oxidative stress DNA damage
On-line přístup:	https://www.mdpi.com/2076-3921/11/12/2438
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