USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity

Abstract Background High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in response to inflammatory stimuli. Several post-translational modificati...

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Bibliografiske detaljer

Principais autores:	Jaemin Shin, Young Hun Kim, Bin Lee, Jae Ho Chang, Hee Youn Choi, Hoojung Lee, Ki Chan Song, Man Sup Kwak, Ji Eun Choi, Jeon-Soo Shin
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2022-12-01
Serier:	Molecular Medicine
Fag:	HMGB1 Deubiquitination USP13 Secretion Spautin-1
Online adgang:	https://doi.org/10.1186/s10020-022-00596-0
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