Sulfatide Inhibits HMGB1 Secretion by Hindering Toll-Like Receptor 4 Localization Within Lipid Rafts

The high mobility group box 1 (HMGB1) is a well-known late mediator of sepsis, secreted by multiple stimuli, involving pathways, such as the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways, and reactive oxygen species (ROS) under inflammation. Sulfatide, in contra...

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Bibliographic Details

Main Authors:	Hee Sue Kim, Myeonggil Han, In Ho Park, Cheol Ho Park, Man Sup Kwak, Jeon-Soo Shin
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Immunology
Subjects:	sulfatide HMGB1 TLR4 lipid raft sepsis NF-κB
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01305/full
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