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Sulfatide Inhibits HMGB1 Secretion by Hindering Toll-Like Receptor 4 Localization Within Lipid Rafts

The high mobility group box 1 (HMGB1) is a well-known late mediator of sepsis, secreted by multiple stimuli, involving pathways, such as the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways, and reactive oxygen species (ROS) under inflammation. Sulfatide, in contra...

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Principais autores: Hee Sue Kim, Myeonggil Han, In Ho Park, Cheol Ho Park, Man Sup Kwak, Jeon-Soo Shin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-06-01
Serier:Frontiers in Immunology
Fag:
sulfatide
HMGB1
TLR4
lipid raft
sepsis
NF-κB
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.01305/full
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