USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity
Abstract Background High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in response to inflammatory stimuli. Several post-translational modificati...
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| Автори: | , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
BMC
2022-12-01
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| Серія: | Molecular Medicine |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1186/s10020-022-00596-0 |
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