Optogenetic engineering of BAX to control mitochondrial permeabilization and attenuate apoptosis in cells

Abstract Although considerable research has focused on enhancing the apoptotic function of BAX for several decades, inhibition of its functionality remains relatively underexplored, despite intensive BAX activation occurring in various neurodegenerative diseases. Here we present a protein engineerin...

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Hlavní autoři:	Dain Lee, Hyunjun Bae, Dongwoo Oh, Minseop Kim, Ju-Hee Kim, Jinchul Ahn, Seok-Hyeon Kang, Seo-Hee You, Dong-Hwee Kim, Hyun Jeong Oh, Won Do Heo, Seok Chung
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2025-12-01
Edice:	Experimental and Molecular Medicine
On-line přístup:	https://doi.org/10.1038/s12276-025-01605-y
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