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Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model

Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response. Conversely, RT also promotes an immunosuppressive TME notably through the recruitme...

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Principais autores: Pierre-Simon Bellaye, Alexandre MM. Dias, Jean-Marc Vrigneaud, Alexanne Bouchard, Mathieu Moreau, Camille Petitot, Claire Bernhard, Michael Claron, Lisa Froidurot, Véronique Morgand, Mélanie Guillemin, Marie Monterrat, Céline Mirjolet, Carmen Garrido, Evelyne Kohli, Bertrand Collin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-10-01
Serier:Heliyon
Fag:
GARP
Targeted radionuclide therapy
T regulatory cells
External beam radiotherapy
SPECT imaging
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024155740
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