GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors

Abstract Most cells produce latent transforming growth factor-beta 1 (TGF-β1), but only very few activate the cytokine via cell type-specific mechanisms. TGF-β1 favors cancer progression by suppressing anti-tumor T cell responses. Which cells produce this immunosuppressive TGF-β1 in human tumors is...

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主要な著者:	Pierre Van Meerbeeck, Douae Maatougui, Grégoire de Streel, Noora Vaherto, Etienne Marbaix, Frank Aboubakar Nana, Marc Van den Eynde, Alix Devaux, Javier Carrasco, Agnès Noel, Nicolas van Baren, Sophie Lucas
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer 2025-09-01
シリーズ:	Cancer Immunology, Immunotherapy
主題:	TGF-β1 GARP Regulatory T cell Tumor infiltrating lymphocyte Quantitative multiplexed immunohistofluorescence Immunosuppression
オンライン･アクセス:	https://doi.org/10.1007/s00262-025-04157-2
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