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Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model

Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response. Conversely, RT also promotes an immunosuppressive TME notably through the recruitme...

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Kaydedildi:
Asıl Yazarlar: Pierre-Simon Bellaye, Alexandre MM. Dias, Jean-Marc Vrigneaud, Alexanne Bouchard, Mathieu Moreau, Camille Petitot, Claire Bernhard, Michael Claron, Lisa Froidurot, Véronique Morgand, Mélanie Guillemin, Marie Monterrat, Céline Mirjolet, Carmen Garrido, Evelyne Kohli, Bertrand Collin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2024-10-01
Seri Bilgileri:Heliyon
Konular:
GARP
Targeted radionuclide therapy
T regulatory cells
External beam radiotherapy
SPECT imaging
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2405844024155740
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