Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8-diaminopelargonic acid synthase, BioA. In biotin-free synthetic media, ΔbioA did not produce wild-type levels of...

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Váldodahkkit:	Sae Woong Park, Marcus Klotzsche, Daniel J Wilson, Helena I Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E Barry, Courtney C Aldrich, Sabine Ehrt, Dirk Schnappinger
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Public Library of Science (PLoS) 2011-09-01
Ráidu:	PLoS Pathogens
Liŋkkat:	http://europepmc.org/articles/PMC3182931?pdf=render
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