Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8-diaminopelargonic acid synthase, BioA. In biotin-free synthetic media, ΔbioA did not produce wild-type levels of...

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Bibliografische gegevens

Hoofdauteurs:	Sae Woong Park, Marcus Klotzsche, Daniel J Wilson, Helena I Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E Barry, Courtney C Aldrich, Sabine Ehrt, Dirk Schnappinger
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Public Library of Science (PLoS) 2011-09-01
Reeks:	PLoS Pathogens
Online toegang:	http://europepmc.org/articles/PMC3182931?pdf=render
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