Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8-diaminopelargonic acid synthase, BioA. In biotin-free synthetic media, ΔbioA did not produce wild-type levels of...

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Үндсэн зохиолчид:	Sae Woong Park, Marcus Klotzsche, Daniel J Wilson, Helena I Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E Barry, Courtney C Aldrich, Sabine Ehrt, Dirk Schnappinger
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2011-09-01
Цуврал:	PLoS Pathogens
Онлайн хандалт:	http://europepmc.org/articles/PMC3182931?pdf=render
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!