Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis

Tuberculosis is a massive global burden and Mycobacterium tuberculosis is increasingly resistant to first- and second-line drugs. There is an acute need for new anti-mycobacterial drugs with novel targets. We previously evaluated a series of 2-aminothiazoles with activity against Mycobacterium tuber...

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Autori principali:	Heather H. Wescott, Edison S. Zuniga, Anumita Bajpai, Carolina Trujillo, Sabine Ehrt, Dirk Schnappinger, David M. Roberts, Tanya Parish
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-10-01
Serie:	Frontiers in Microbiology
Soggetti:	anti-bacterial activity glycolysis drug target tuberculosis drug target discovery anti-tubercular
Accesso online:	https://www.frontiersin.org/article/10.3389/fmicb.2018.02542/full
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